He went on to say, “so when they stand up, they have postural syncope. ![]() Some individuals have autonomic instability that may be related to their narcolepsy. Non-dipping is not good, and narcolepsy patients are non-dippers as a group, Bogan said, so anything that can be done to decrease cardiovascular risk is something they keep in mind. This can be used as a measure of sleep quality as to whether you’re in deep sleep or not. So, when we’re using medication for the rest of their lives, potentially, we pay a lot of attention to sodium intake,” he continued.īogan went on to say that individuals with narcolepsy over the years sometimes develop some other disorders that sodium intake can have an impact on that health care providers take into an account.Īnother interesting finding was “dipping,” which is when a person's heart rate and blood pressure drop when they go to sleep at night. “These oxybate molecules are indicated for the treatment in patients with narcolepsy, and, interestingly, narcolepsy patients have a higher prevalence of cardiovascular disease, diabetes, and obesity. Patients with narcolepsy, interestingly, have a higher prevalence of comorbidities, and their disorder is lifelong,” Bogan said. “We all recognize that monitoring sodium intake, particularly in vulnerable populations. So, patients with narcolepsy are at higher risk of developing cardiovascular and cardiometabolic disease. Of course, hypertension can lead to vascular disease, strokes, chronic renal failure all of those are important."Įxposure to high-sodium medications such as SXB is an extra contribution to total daily sodium intake, and high sodium intake over a lifetime, as what may be required by patients with narcolepsy, may confer risk in younger, apparently healthy individuals. "Chronic, higher sodium levels of intake put people at risk primarily for cardiovascular problems and hypertension. “There’s a lot of literature that says that sodium intake has an effect on chronic disease, mainly cardiovascular and renal status," said Bogan. SXB treatment contributes to 1100 to 1640 mg of daily sodium intake, and sodium intake increases the risk of hypertension and cardiovascular outcomes, especially stroke, separate from blood pressure. One symptom of narcolepsy is cataplexy, for which SXB is an approved treatment. ![]() Narcolepsy is a chronic neurologic disorder that seriously impairs quality of life, productivity, and social functioning, necessitating long-term treatment in multiple patients, and possesses a global estimated prevalence of 0.02% to 0.067%.
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